SLU-PP-332

Metabolic / Fat Loss / Energy Expenditure
•In diet-induced obese (DIO) mice, SLU-PP-332 treatment (50 mg/kg, i.p., twice daily) led to ~12% weight loss after 28 days even while the mice stayed on a high-fat diet.  
•The treated mice had less increase in fat mass, improved glucose tolerance, lower fasting insulin, and reduced hepatic triglyceride accumulation.  
•Importantly, food intake did not decrease in the treated mice — the effects appear driven by increased energy expenditure / substrate oxidation rather than appetite suppression.  
•Indirect calorimetry data: SLU-PP-332 reduced the respiratory exchange ratio (RER), indicating a shift toward greater fatty acid oxidation vs carbohydrate oxidation, and it increased resting energy expenditure.  
Mitochondrial / Muscle / Exercise-Like Effects
•In muscle cell lines, SLU-PP-332 enhances mitochondrial function and respiration.  
•In mice, it increased endurance / exercise capacity, and induced gene expression changes typical of acute aerobic exercise (in an ERRα-dependent fashion)  
•It also promoted more oxidative (endurance) muscle fiber characteristics (e.g. shifting toward type IIa oxidative fibers) in preclinical models.