SLU-PP-332

Metabolic / Fat Loss / Energy Expenditure

• In diet-induced obese (DIO) mice, SLU-PP-332 treatment (50 mg/kg, i.p., twice daily) led to ~12% weight loss after 28 days even while the mice stayed on a high-fat diet.

• The treated mice had less increase in fat mass, improved glucose tolerance, lower fasting insulin, and reduced hepatic triglyceride accumulation.

• Importantly, food intake did not decrease in the treated mice — the effects appear driven by increased energy expenditure / substrate oxidation rather than appetite suppression.

• Indirect calorimetry data: SLU-PP-332 reduced the respiratory exchange ratio (RER), indicating a shift toward greater fatty acid oxidation vs carbohydrate oxidation, and it increased resting energy expenditure.

Mitochondrial / Muscle / Exercise-Like Effects

• In muscle cell lines, SLU-PP-332 enhances mitochondrial function and respiration.

• In mice, it increased endurance / exercise capacity, and induced gene expression changes typical of acute aerobic exercise (in an ERRα-dependent fashion)

• It also promoted more oxidative (endurance) muscle fiber characteristics (e.g. shifting toward type IIa oxidative fibers) in preclinical models.